It is this particular feature that makes these species extremely valuable in transplantation, oncology, and immunology research. Since these species do not exhibit normal immunological responses (e.g., fighting infections or rejection of tumors or transplants), they have been extensively used as biological hosts for tissue transplants since. In addition to inhibiting their immune system, this mutation also causes a lack of hair growth in the animals, hence their name. Nude mice also ^ undergo a genetic mutation (disruption of the FOXN1 gene) that leads to a lack of, or deteriorated thymus gland and inability to produce T lymphocytes.
SCID (severe combined immunodeficiency) mice lack the ability to make T or B lymphocytes due to a genetic mutation in chromosome 16. There are two main species of immunodeficient mice used in research today: SCID and Nude mice. Anticancer Research 2006 26(4B): 3011-3015) Immunodeficient mouse models have been an integral part of pre-clinical research, and have contributed to significant advances in oncology, transplantation, immunology and stem cell biology research. Ann Rheum Dis 2009 68:124-129) “The comparative experiments (injection and infusion) confirmed that continuous treatments and long-term administration were associated with the best treatment responses.” (Tejeda, M, et al. Use of ALZET® Osmotic Pumps in Immunodeficient Mouse Models LJ\ “The combination of the established SCID mouse model for RA and the long-term osmotic pump-based delivery system for bioactive molecules adds a novel tool for the detailed analysis of RA pathophysiology.” (Knedla, A, et al.
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